Free tool
Can I eat this with Methadone?
Grapefruit can make side effects worse, and alcohol increases the risk of serious breathing and sedation problems.
Also sold as Eptadone, Methadose, Metharose, Synastone. Brand names from the NHS Dictionary of Medicines and Devices.
Type any food below for an instant verdict — we check 58 foods and drinks for Methadone (39 to avoid, 8 to take care with) — or tap one below.
Quick answers
- Can I eat grapefruit with Methadone?
- No, avoid it. It can make side effects worse.
- Can I drink alcohol with Methadone?
- No, avoid it. It increases the risk of serious side effects including breathing problems.
- Can I eat rich or spicy food with Methadone?
- Yes, with care. Avoid them if you feel sick.
- Can I eat spicy food with Methadone?
- Yes, with care. Rich or spicy food can make nausea worse; avoid them if you feel sick.
Grounded in the checker below. Not a substitute for your pharmacist.
1 · What do you take?
Grapefruit can make side effects worse, and alcohol increases the risk of serious breathing and sedation problems.
Avoid grapefruit and alcohol while taking methadone. Grapefruit can worsen side effects, and alcohol increases the risk of serious breathing problems and sedation. If you feel sick, taking methadone with food may help, and simple meals are easier on the stomach. For constipation, more fibre and water can help.
Browse our medication food guides →2 · What do you want to eat or drink?
Tap a food to see the answer, or type any food or drink in the box above.
Foods to avoid with Methadone· 39
Take care with Methadone· 8
Fine with Methadone· 11
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This checker summarises published guidance (NHS medicine pages, patient information leaflets and drug labels) for general information only. It is not medical advice, it is not exhaustive, and it cannot account for your dose, kidney function, other medicines, or health conditions. Always follow your prescriber, pharmacist, or the patient information leaflet — especially before changing what you eat or drink. See our editorial policy.
Further reading on Methadone
The pages our answers quote. Every answer shows “Where this comes from” with the exact words, checked 24 September 2026. How we check
NHS website
About methadone
NHS medicines information on methadone – what it's used for and key facts.
NHS website
Who can and cannot take methadone
NHS medicines information on who can take methadone and who may not be able to take it.
NHS website
How and when to take methadone
NHS medicines information on dosage for methadone, how to take it and what to do if you miss a dose or take too much.
NHS website
Side effects of methadone
NHS medicines information on side effects of methadone and what you can do to cope.
NHS website
Taking methadone with other medicines and herbal supplements
NHS medicines information on possible interactions with methadone and other medicines, herbal remedies and supplements.
The Journal
Read our medication food guides →
A full Methadone guide is on its way. Meanwhile, the Journal covers timing, grapefruit, alcohol and more.
Food groups that matter with Methadone
Every medicine each one affects, on one page.
Medicines with similar food rules
Affected by the same foods as Methadone.