Free tool
Can I eat this with Sertraline?
Grapefruit juice and alcohol are the main drink concerns with sertraline, and St John's wort should not be taken with it. It can be taken with or without food.
Also sold as Contulen, Lustral. Brand names from the NHS Dictionary of Medicines and Devices.
Our SSRIs page also covers Sertraline and gives one answer for the whole group. This page follows Sertraline’s own NHS page, so where the two differ, go by this one.
Type any food below for an instant verdict — we check 46 foods and drinks for Sertraline (12 to avoid, 26 to take care with) — or tap one below.
Quick answers
- Should I take Sertraline with food?
- Take once a day at the same time, with or without food.
- Can I drink grapefruit juice with Sertraline?
- No, avoid it. Do not drink grapefruit juice while you are taking sertraline.
- Can I eat st john's wort with Sertraline?
- No, avoid it. Do not use St John's wort supplements while taking sertraline.
- Can I eat grapefruit with Sertraline?
- No, avoid it. Grapefruit juice should be avoided entirely while you take sertraline.
- Can I drink alcohol with Sertraline?
- Yes, with care. It is best not to drink alcohol, as it can stop sertraline working properly.
Grounded in the checker below and the full guide. Not a substitute for your pharmacist.
1 · What do you take?
Grapefruit juice and alcohol are the main drink concerns with sertraline, and St John's wort should not be taken with it. It can be taken with or without food.
Do not drink grapefruit juice while taking sertraline, and it is best not to drink alcohol because it can stop the medicine working properly. Do not use the herbal supplement St John's wort. You can take sertraline with or without food.
Read our full Sertraline guide →2 · What do you want to eat or drink?
When to take it: Take once a day at the same time, with or without food.
Tap a food to see the answer, or type any food or drink in the box above.
Foods to avoid with Sertraline· 12
Take care with Sertraline· 26
Fine with Sertraline· 8
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This checker summarises published guidance (NHS medicine pages, patient information leaflets and drug labels) for general information only. It is not medical advice, it is not exhaustive, and it cannot account for your dose, kidney function, other medicines, or health conditions. Always follow your prescriber, pharmacist, or the patient information leaflet — especially before changing what you eat or drink. See our editorial policy.
Further reading on Sertraline
The pages our answers quote. Every answer shows “Where this comes from” with the exact words, checked 6 October 2026. How we check
Food groups that matter with Sertraline
Every medicine each one affects, on one page.
Medicines with similar food rules
Affected by the same foods as Sertraline.